Ground Truths

Eric Topol
Facts, data, and analytics about Covid and other biomedical matters.
Created 30 Nov 2021
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  • A new wave and a new booster?
    29 Mar 2022
    The inconvenient truth is that we are going to experience a new BA.2 variant wave in the United States—the magnitude of which remains uncertain—and, this highlights the question of whether a 2nd boost...
  • The Epidemic of Covid Complacency
    06 Mar 2022
    Isn’t it great? The pandemic is over. We don’t need masks. The virus is contained. Forget about vaccines since they don’t work. The vulnerable are protected. Future variants will be benign. The only p...
  • Ground Truths on Prior Covid
    12 Feb 2022
    Last week, a physician wrote a piece in The Lancet entitled “Health-care workers recovered from natural SARS-CoV-2 infection should be exempt from mandatory vaccination edicts” Dr. McGonagle pointed t...
  • How to misinterpret clinical outcome data in populations by age subgroups
    06 Feb 2022
    Recently a headline in the New York Times was “Younger People Benefit Less From Boosters Than Older”. Of course they do, as risk of nearly any intervention in medicine along with its absolute benefit ...
  • A Shot in the Dark
    29 Jan 2022
    It would not have been foreseen that a vaccine directed to the original, ancestral SARS-CoV-2 strain would hold up so well against one that evolved over 2 years, after hundreds of millions of infectio...
  • Where do we stand with Omicron?
    22 Jan 2022
    There has been a flood of new data in the past few weeks regarding Omicron’s impact throughout the world, and specifically on the influence of vaccination (with or without boosters) on symptomatic inf...
  • We're very lucky
    09 Jan 2022
    Now into the third year of the Covid pandemic, it’s beyond disheartening. But there’s another way to look at it that’s far more upbeat, not losing sight of good fortune, invoking the Pollyanna princip...
  • Humans 2, Omicron 1
    04 Jan 2022
    It's pretty impressive that vaccines directed to the ancestral strain spike from 2 years ago, with the virus that's evolved through nearly 300 million confirmed cases, and now to the hyper-mutated Omi...
  • The very bad day at the CDC
    28 Dec 2021
    One of my favorite books this year was Michael Lewis’s The Premonition: A Pandemic Story, a page-turner in which he traced the problematic issues of the CDC long before and intra-Covid-19 and gave it ...
  • Inching closer towards a variant-proof, pan- coronavirus vaccine
    28 Dec 2021
    We teamed up to review the implications and progress towards a vaccine that would be effective against the beta-coronavirus family, including all variants of SARS-CoV-2 Why would this be needed? While...
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